Tigers starter Casey Mize has struggled recently, and our expert MLB predictions expect his struggles to continue tonight against Bobby Witt Jr and the Royals.
Photo By – Imagn Images. Casey Mize of the Detroit Tigers.
The Kansas City Royals head to Comerica Park tonight for the beginning of a three-game set with the Detroit Tigers.
Casey Mize has been struggling lately, and I’m expecting that trend to continue in the series opener.
Read more in my MLB picks for Friday, August 22.
Royals vs Tigers prediction
Royals vs Tigers best bet: Casey Mize Over 2.5 earned runs (+120)
Casey Mize was named an All-Star this season and has served as one of Detroit Tigers best arms behind reigning Cy Young award winner Tarik Skubal. However, he’s hit a lull as of late. The right-hander had an ERA over six in July, and that’s barely improved in August.
Across three starts, Mize owns a 4.67 ERA this month. While his ERA still sits at 3.63 on the year, he’s allowed Over 2.5 earned runs in two of his previous three outings. Mize surrendered four earned runs last time out against the Los Angeles Angels.
At home, Mize’s ERA is 3.48. Respectable, but he also gave up three earned runs earlier this season when he faced the Kansas City Royals. The 28-year-old is struggling to find his best right now, and while I won’t say he’s going to get tagged for a ton of runs, Detroit will need to give him some run support here.
Royals vs Tigers same-game parlay (SGP)
We’re going to feed off my best bet and focus on two Royals hitters for my SGP. Salvador Perez is 13-for-30 lifetime against Mize. He’s absolutely torn the cover off the baseball when the righty is on the hill.
Perez has also cashed the Over in hits in three consecutive games. He finished 2-for-4 in the finale against the Texas Rangers on Thursday night and is hitting .247 on the year.
As for Bobby Witt Jr, we all know what he’s about. Witt Jr is hitting .295 with 18 home runs this season. He’s batting .338 in August and has cashed the Over in hits in back-to-back games.
The shortstop has five hits across his last two contests. He’s also had boatloads of success against Mize, going 6-for-14 with a pair of round-trippers. Witt Jr will keep it rolling tonight.
Royals vs Tigers odds
- Moneyline: Kansas City +135 | Detroit -160
- Run line: Kansas City +1.5 (-160) | Detroit -1.5 (+135)
- Over/Under: Over 8.5 (-110) | Under 8.5 (-110)
Royals vs Tigers trend
The Kansas City Royals have covered the Run Line in 35 of their last 50 away games (+17.00 Units / 23% ROI). Find more MLB betting trends for Royals vs. Tigers.
How to watch Royals vs Tigers and game info
| Location | Comerica Park, Detroit, MI |
| Date | Friday, August 22, 2025 |
| First pitch | 7:10 p.m. ET |
| TV | Apple TV+ |
| Royals starting pitcher | Ryan Bergert (1-1, 2.75 ERA) |
| Tigers starting pitcher | Casey Mize (12-4, 3.63 ERA) |
Royals vs Tigers latest injuries
Royals vs Tigers weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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