Guardians vs. Royals Prediction, Odds, Picks – September 11

Data Skrive

Jose Ramirez and the Cleveland Guardians head into the final of a four-game series against Maikel Garcia and the Kansas City Royals at Progressive Field, Thursday at 7:15 p.m. ET. The favored Guardians have -140 moneyline odds to win against the underdog Royals, who are listed at +118. Cleveland is the favorite on the run line (-1.5). The total is 7.5 runs for this contest.

Here is everything you need to know from a betting perspective on the Guardians-Royals game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Guardians vs. Royals Game Information & Odds

• When: Thursday, September 11, 2025 at 7:15 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: FOX

Guardians vs. Royals Prediction

• Score Prediction: Guardians 5, Royals 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Guardians 52%, Royals 48%

Guardians vs. Royals Betting Insights

• The Guardians have entered the game as favorites 60 times this season and won 36, or 60%, of those games.
• Cleveland has a record of 11-5 in games when oddsmakers favor them by at least -140 on the moneyline.
• The implied probability of a win from the Guardians, based on the moneyline, is 58.3%.
• The Royals have been underdogs in 82 games this season and have come away with the win 38 times (46.3%) in those contests.
• This season, Kansas City has been victorious 18 times in 37 chances when named as an underdog of at least +118 or longer on the moneyline.
• The moneyline set for this matchup implies the Royals have a 45.9% chance of walking away with the win.

Guardians Recent Betting Performance

• The Guardians were the moneyline favorite for three of their last 10 games, and they went 2-1 in those matchups.
• Over their last 10 matchups, the Guardians and their opponents combined to go over the run total four times (all 10 of the games had set totals).
• The Guardians are 7-3-0 against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Not only does Ramirez lead the Guardians in hitting with his .287 average, he also is their foremost power hitter with 28 home runs and 76 RBI.
• Among all hitters in the majors, Ramirez is 21st in homers and 45th in RBI.
• Ramirez has collected a hit in seven games in a row. In his last 10 outings he is batting .342 with four doubles, a triple, two home runs, three walks and eight RBIs.
• Steven Kwan has 25 doubles, a triple, 10 home runs and 50 walks while hitting .276.
• Kwan is 187th in home runs and 164th in RBI among all MLB hitters this season.
• Kyle Manzardo is hitting .240 with 15 doubles, two triples, 26 home runs and 46 walks.
• Manzardo will look to build on his three-game hitting in this matchup. In his last five games he is hitting .400 with a double, two home runs, four walks and five RBIs.
• Angel Martinez is hitting .225 with 21 doubles, a triple, 10 home runs and 18 walks.

Guardians Team Props

Royals Recent Betting Performance

• In five games as underdogs over the last 10 matchups, the Royals have a record of 2-3.
• In their last 10 games with a total, the Royals and their opponents are 2-8-0 when it comes to hitting the over.
• The Royals have one win against the spread in their last 10 chances.

Royals Recent Stats

Royals Player Insights

• Bobby Witt Jr. paces the Royals with a team-high batting average of .295.
• In all of the majors, Witt ranks 60th in homers and 42nd in RBI.
• Garcia has 36 doubles, five triples, 16 home runs and 54 walks while batting .292.
• Garcia is 110th in homers and 72nd in RBI among all MLB hitters this season.
• Vinnie Pasquantino has been solid source of run production for the Royals with 29 long balls and 100 runs batted in.
• Salvador Perez has 34 doubles, 25 home runs and 23 walks while hitting .235.

Royals Team Props

Royals vs. Guardians Highlights | MLB on FOX

Enjoy the best moments between Kansas City Royals and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.