Blue Jays vs. Royals Prediction, Odds, Picks – September 21

Data Skrive

Michael Wacha will take the mound for the Kansas City Royals looking to slow down George Springer and the Toronto Blue Jays on Sunday at 2:10 p.m. ET. The Blue Jays are favored in this one, at -114, while the underdog Royals have -106 odds to win. Toronto is the run-line favorite (-1.5). The total is 9 runs for this contest (with -110 odds to go over and -110 odds on the under).

Here is everything you need from a betting perspective on the Blue Jays-Royals game, regarding the run line, moneyline and total, plus expert picks.

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Blue Jays vs. Royals Game Information & Odds

• When: Sunday, September 21, 2025 at 2:10 p.m. ET
• Where: Kauffman Stadium in Kansas City, Missouri
• How to watch on TV: FDSKC and SNET

Blue Jays vs. Royals Prediction

• Score Prediction: Royals 5, Blue Jays 4
• Total Prediction: Under 9 runs
• Win Probabilities: Blue Jays 50%, Royals 50%

Blue Jays vs. Royals Betting Insights

• This season, the Blue Jays have been favored 79 times and won 46, or 58.2%, of those games.
• This season Toronto has won 43 of its 75 games, or 57.3%, when favored by at least -114 on the moneyline.
• The oddsmakers’ moneyline implies a 53.3% chance of a victory for the Blue Jays.
• The Royals have been victorious in 40, or 44.9%, of the 89 contests they have been chosen as underdogs in this season.
• Kansas City has a mark of 35-46 in contests where bookmakers favor it by -106 or worse on the moneyline.
• The moneyline set for this matchup implies the Royals have a 51.5% chance of coming away with a victory in the contest.

Blue Jays Recent Betting Performance

• The Blue Jays have a 5-4 record over the nine games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups, the Blue Jays and their opponents combined to hit the over four times (all 10 of the games had set totals).
• The Blue Jays’ ATS record is 3-7-0 over their past 10 games.

Blue Jays Recent Stats

Blue Jays Player Insights

• Vladimir Guerrero Jr. has 33 doubles, 23 home runs and 80 walks while hitting .298.
• Guerrero is 55th in homers and 39th in RBI among all hitters in MLB.
• Springer’s 30 home runs are a team-high mark.
• Springer ranks 18th in homers and 48th in RBI in the bigs.
• Ernie Clement has 33 doubles, two triples, nine home runs and 25 walks while hitting .279.
• Alejandro Kirk has 17 doubles, 12 home runs and 46 walks while hitting .287.

Royals Recent Betting Performance

• In nine games over the last 10 matchups when set as underdogs by sportsbooks, the Royals had a record of 3-6.
• In their last 10 games with a total, the Royals and their opponents have failed to hit the over four times.
• The Royals are 4-6-0 ATS over their last 10 games.

Royals Recent Stats

Royals Player Insights

• Bobby Witt Jr. leads the Royals with a team-leading batting average of .292.
• Witt’s home run total puts him 60th in the majors, and he ranks 39th in RBI.
• Maikel Garcia is batting .285 with 36 doubles, five triples, 16 home runs and 59 walks.
• Garcia is currently 120th in home runs and 79th in RBI in the big leagues.
• Vinnie Pasquantino paces the Royals in home runs (30) and runs batted in (106).
• Salvador Perez has swatted a team-leading 30 long balls.

Blue Jays vs. Royals Highlights | MLB on FOX

Check out the best highlights between the Toronto Blue Jays and Kansas City Royals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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