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The Grey\u2019s Anatomy <\/i><\/a>cast has seemingly confirmed that fans are right to be worried about whether their favorite characters survive the season 22 premiere.<\/p>\n \u201cThe premiere in one word? Deadly,\u201d Jason George<\/strong>, who plays surgical resident Ben Warren, quipped in a Saturday, September 27, Instagram<\/a> video shared by the show\u2019s official account.<\/p>\n His costar Kevin McKidd<\/strong> (Owen Hunt) chimed in to call the episode \u201cbreathtaking,\u201d while Camilla Luddington<\/strong> (Jo Wilson) went with \u201cjaw-dropping.\u201d Anthony Hill<\/strong> (Winston Ndugu) later used the word \u201cconvalesces\u201d and Alexis Floyd<\/strong> (Simone Griffith) chose \u201cclean-up job.\u201d<\/p>\n Newcomer Trevor Jackson<\/strong>, who will play one of the new surgical residents, further teased that the premiere is \u201cfresh,\u201d just as Kim Raver<\/strong> (Teddy Altman) hinted at plenty of drama.<\/p>\n Which \u2018Grey\u2019s Anatomy\u2019 Stars Are \u2014 And Aren\u2019t \u2014 Returning for Season 22 After Hospital Explosion?<\/a><\/p>\n \u201cEdge of your seat,\u201d Raver, 56, quipped.<\/p>\n The season 21 finale ended on a major cliffhanger after guest star Piper Perabo<\/strong> unknowingly brought a full tank of oxygen into an operating room at Grey Sloan Memorial. (Perabo, 48, thought the tank was empty, using it as a threat to get the doctors to perform a risky surgery on her chronically ill child.)<\/p>\n By the end of the episode, fans learned that the tank actually wasn\u2019t empty before there was an explosion on the O.R. floor. It\u2019s not known which characters were safe<\/a> from the blast as the likes of Atticus Lincoln (Chris Carmack<\/strong>) and Miranda Bailey (Chandra Wilson<\/strong>) were in respective surgeries. (Ellen Pompeo<\/strong>\u2019s Meredith Grey and Luddington\u2019s Jo, meanwhile, are likely safe since they were both spotted outside the medical facility at the time of the explosion.)<\/p>\n