Sheinelle Jones<\/a>\u2018 second day as the fourth of Today<\/a><\/em>\u2018s new cohost<\/a> featured a very special guest.<\/p>\n Oprah Winfrey<\/a> stopped by the NBC morning show to promote her new book, Enough: Your Health, Your Weight, and What It\u2019s Like To Be Free<\/em><\/a>, which she cowrote with endocrinologist and associate professor at the Yale School of Medicine Dr. Ania M. Jastreboff. While reflecting on her weight-loss journey, Winfrey shared some surprising side effects she\u2019s experienced while taking a GLP-1 medication.<\/p>\n Jastreboff stated that the most common symptoms for people taking weight-loss medication include nausea, diarrhea, and constipation.<\/p>\n \u201cI never had nausea or diarrhea, but I did have the third one,\u201d Winfrey stated. \u201cI finally figured out, for me, what the right combination of magnesium and water is. I have to drink a lot of water. I have to have a gallon of water a day.\u201d<\/p>\n According to Winfrey, she has to finish drinking her gallon of water before 4 p.m., or else she will be up all night. While drinking lots of water makes Winfrey\u2019s kidneys \u201cvery happy,\u201d Jastreboff said there are other ways to \u201clessen nausea\u201d while on weight-loss medication.<\/p>\n \u201cThe most important way is working with your healthcare provider and going up very, very slowly. So, start slow, go slow. If you\u2019re feeling nauseated, then don\u2019t increase the dose,\u201d she explained. \u201cAnd there\u2019s other things \u2014 not eating past the point of fullness, making sure you\u2019re monitoring which foods could make you worse. All of these different things can lower the side effects.\u201d<\/p>\n