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Jose Ramirez and the Cleveland Guardians take on Bobby Witt Jr. and the Kansas City Royals on Tuesday at 6:40 p.m. ET in the second game of a four-game series. The Royals are listed as +109 moneyline underdogs for this matchup against the favorite Guardians (-129). Cleveland is favored on the run line (-1.5). The total is 7.5 runs for this matchup.
Check out everything you need from a betting perspective on the Guardians-Royals game, regarding the run line, moneyline and total, plus expert picks.
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Guardians vs. Royals Game Information & Odds
- When: Tuesday, September 9, 2025 at 6:40 p.m. ET
- Where: Progressive Field in Cleveland, Ohio
- How to watch on TV: CLEG and FDSKC
- Score Prediction: Guardians 4, Royals 3
- Total Prediction: Under 7.5 runs
- Win Probabilities: Guardians 53%, Royals 47%
- This season, the Guardians have won 35 out of the 58 games, or 60.3%, in which they’ve been favored.
- Cleveland has a record of 23-10, a 69.7% win rate, when favored by -129 or more by sportsbooks this season.
- The moneyline for this contest implies a 56.3% chance of a victory for the Guardians.
- The Royals have been underdogs in 80 games this season and have come away with the win 37 times (46.2%) in those contests.
- This season, Kansas City has come away with a win 20 times in 49 chances when named as an underdog of at least +109 or worse on the moneyline.
- The moneyline set for this matchup implies the Royals have a 47.8% chance of coming away with a victory in the contest.
- The Guardians have been listed as the moneyline favorite by bookmakers only one time over the last 10 games, and won that matchup.
- In their last 10 outings (all 10 of them had set totals), the Guardians and their opponents combined to hit the over four times.
- The Guardians are 6-4-0 against the spread over their past 10 games.
- Not only does Ramirez lead the Guardians in hitting with his .283 average, he also paces the squad with 27 home runs and 75 RBI.
- In all of Major League Baseball, Ramirez ranks 25th in homers and 47th in RBI.
- Ramirez takes a hitting streak of five games into this matchup. In his last five games he is hitting .400 with two doubles, a triple, a home run, a walk and five RBIs.
- Steven Kwan has 25 doubles, a triple, 10 home runs and 49 walks while hitting .277.
- Kwan is 185th in home runs and 160th in RBI among all MLB batters this season.
- Kwan carries a four-game streak with at least one hit into this contest. During his last five outings he is hitting .350 with four walks and four RBIs.
- Kyle Manzardo has 15 doubles, two triples, 25 home runs and 45 walks while hitting .239.
- Manzardo is on a two-game hitting streak entering this contest. During his last five outings he is batting .375 with a double, a home run, four walks and four RBIs.
- Angel Martinez is hitting .226 with 21 doubles, a triple, 10 home runs and 17 walks.
- In four games over the last 10 matchups when set as underdogs by oddsmakers, the Royals had a record of 2-2.
- The Royals and their opponents have combined to hit the over two times in their last 10 games with a total.
- The Royals have a record of 2-8-0 ATS over their last 10 games.
- Witt leads the team in batting average with a mark of .294.
- In all of the big leagues, Witt is 59th in home runs and 41st in RBI.
- Maikel Garcia is hitting .292 with 35 doubles, five triples, 16 home runs and 54 walks.
- Among all MLB hitters, Garcia ranks 107th in homers and 70th in RBI.
- Vinnie Pasquantino leads the Royals in home runs (29) and runs batted in (99).
- Salvador Perez is hitting .237 with 33 doubles, 25 home runs and 23 walks.
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