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Patrick Dempsey Explains His Darker TV Return With ‘Memory of a Killer’: “I Don’t Get This Type of Character Offered Often”

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March 17, 2026
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Patrick Dempsey Explains His Darker TV Return With ‘Memory of a Killer’: “I Don’t Get This Type of Character Offered Often”

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[This interview contains spoilers from the March 16 episode of Memory of a Killer.]

Patrick Dempsey has never played a character quite like with his starring role on Fox’s Memory of a Killer. More than a decade after leaving Grey’s Anatomy, the ABC medical drama where he played legendary neurosurgeon Dr. Derek “McDreamy” Shepherd for 11 seasons, Dempsey has stepped into the role of a cold-blooded contract killer who struggles to keep his double life a secret after experiencing symptoms of early onset Alzheimer’s — the same disease, ironically, that Derek spent years researching on Grey’s.

“What was really appealing was the assassin side, and certainly the Alzheimer’s and the dementia side,” Dempsey tells The Hollywood Reporter of his long-awaited return to network TV. “I don’t get this type of character offered to me very often, and it came to me very quickly. I had to read it and then had to make a decision within 24 hours,…

‘ The preceding article may include information circulated by third parties ’

‘ Some details of this article were extracted from the following source www.imdb.com ’

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