Guardians vs. Royals Prediction, Odds, Picks – September 9

Data Skrive

Jose Ramirez and the Cleveland Guardians take on Bobby Witt Jr. and the Kansas City Royals on Tuesday at 6:40 p.m. ET in the second game of a four-game series. The Royals are listed as +109 moneyline underdogs for this matchup against the favorite Guardians (-129). Cleveland is favored on the run line (-1.5). The total is 7.5 runs for this matchup.

Check out everything you need from a betting perspective on the Guardians-Royals game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Royals Game Information & Odds

• When: Tuesday, September 9, 2025 at 6:40 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and FDSKC

Guardians vs. Royals Prediction

• Score Prediction: Guardians 4, Royals 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Guardians 53%, Royals 47%

Guardians vs. Royals Betting Insights

• This season, the Guardians have won 35 out of the 58 games, or 60.3%, in which they’ve been favored.
• Cleveland has a record of 23-10, a 69.7% win rate, when favored by -129 or more by sportsbooks this season.
• The moneyline for this contest implies a 56.3% chance of a victory for the Guardians.
• The Royals have been underdogs in 80 games this season and have come away with the win 37 times (46.2%) in those contests.
• This season, Kansas City has come away with a win 20 times in 49 chances when named as an underdog of at least +109 or worse on the moneyline.
• The moneyline set for this matchup implies the Royals have a 47.8% chance of coming away with a victory in the contest.

Guardians Recent Betting Performance

• The Guardians have been listed as the moneyline favorite by bookmakers only one time over the last 10 games, and won that matchup.
• In their last 10 outings (all 10 of them had set totals), the Guardians and their opponents combined to hit the over four times.
• The Guardians are 6-4-0 against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Not only does Ramirez lead the Guardians in hitting with his .283 average, he also paces the squad with 27 home runs and 75 RBI.
• In all of Major League Baseball, Ramirez ranks 25th in homers and 47th in RBI.
• Ramirez takes a hitting streak of five games into this matchup. In his last five games he is hitting .400 with two doubles, a triple, a home run, a walk and five RBIs.
• Steven Kwan has 25 doubles, a triple, 10 home runs and 49 walks while hitting .277.
• Kwan is 185th in home runs and 160th in RBI among all MLB batters this season.
• Kwan carries a four-game streak with at least one hit into this contest. During his last five outings he is hitting .350 with four walks and four RBIs.
• Kyle Manzardo has 15 doubles, two triples, 25 home runs and 45 walks while hitting .239.
• Manzardo is on a two-game hitting streak entering this contest. During his last five outings he is batting .375 with a double, a home run, four walks and four RBIs.
• Angel Martinez is hitting .226 with 21 doubles, a triple, 10 home runs and 17 walks.

Guardians Team Props

Royals Recent Betting Performance

• In four games over the last 10 matchups when set as underdogs by oddsmakers, the Royals had a record of 2-2.
• The Royals and their opponents have combined to hit the over two times in their last 10 games with a total.
• The Royals have a record of 2-8-0 ATS over their last 10 games.

Royals Recent Stats

Royals Player Insights

• Witt leads the team in batting average with a mark of .294.
• In all of the big leagues, Witt is 59th in home runs and 41st in RBI.
• Maikel Garcia is hitting .292 with 35 doubles, five triples, 16 home runs and 54 walks.
• Among all MLB hitters, Garcia ranks 107th in homers and 70th in RBI.
• Vinnie Pasquantino leads the Royals in home runs (29) and runs batted in (99).
• Salvador Perez is hitting .237 with 33 doubles, 25 home runs and 23 walks.

Royals Team Props

Royals vs. Guardians Highlights | MLB on FOX

Check out the best moments between Kansas City Royals and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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