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The Los Angeles Angels and Kansas City Royals will send Yusei Kikuchi and Stephen Kolek, respectively, out for the start when the two clubs play on Wednesday at Angel Stadium, at 9:38 p.m. ET. The Angels are -124 moneyline favorites in this matchup against the Royals (+104). Los Angeles is the run-line favorite (-1.5). An 8.5-run over/under has been set for the contest.
Here is everything you need from a betting perspective on the Angels-Royals game, regarding the run line, moneyline and total, plus expert picks.
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Angels vs. Royals Game Information & Odds
- When: Wednesday, September 24, 2025 at 9:38 p.m. ET
- Where: Angel Stadium in Anaheim, California
- How to watch on TV: FDSW and FDSKC
- Score Prediction: Royals 6, Angels 5
- Total Prediction: Over 8.5 runs
- Win Probabilities: Angels 50%, Royals 50%
- The Angels have entered the game as favorites 39 times this season and won 19, or 48.7%, of those games.
- Los Angeles is 14-15 this season when entering a game favored by -124 or more on the moneyline.
- The Angels have a 55.4% chance to win this game based on the implied probability of the moneyline.
- The Royals have won in 41, or 45.1%, of the 91 contests they have been named as odds-on underdogs this year.
- This year, Kansas City has won 28 of 68 games when listed as at least +104 or worse on the moneyline.
- Oddsmakers have implied with the moneyline set for this matchup that the Royals have a 49% chance of pulling out a win.
- In the last 10 games, the Angels were listed as the moneyline favorite by oddsmakers only twice, and they split those games.
- Over their last 10 matchups, the Angels and their opponents combined to go over the run total six times (all 10 games had set totals).
- The Angels have gone 2-8-0 against the spread over their past 10 games.
- Taylor Ward is the Angels RBI leader this season, knocking in 102 runs to go with his 35 home runs and .228 batting average.
- Among all MLB hitters, Ward is 136th in batting average, 100th in on-base percentage, and 35th in slugging.
- Ward brings a hitting streak of six games into this game. In his last 10 outings he is batting .256 with five home runs and five RBIs.
- Jo Adell’s 36 home runs are a team-high mark.
- Adell ranks ninth in homers and 17th in RBI among all hitters in the majors.
- Adell enters this game looking for his third game in a row with a hit. In his last five games he is batting .222 with two walks and an RBI.
- Nolan Schanuel leads the Angels with a .268 batting average.
- Schanuel has at least one base hit in four games in a row. In his last five games he is batting .294 with a double, a home run, two walks and three RBIs.
- Mike Trout has 14 doubles, a triple, 22 home runs and 86 walks while hitting .227.
- In eight games as underdogs over the last 10 matchups, the Royals have a record of 3-5.
- When it comes to hitting the over, the Royals and their opponents are 8-2-0 in their last 10 games with a total.
- The Royals have five wins against the spread in their last 10 chances.
- Bobby Witt Jr. leads the Royals with a team-leading batting average of .293.
- In all of the big leagues, Witt is 56th in homers and 35th in RBI.
- Witt carries a four-game hitting streak into this matchup. In his last five games he is batting .304 with two doubles, a home run and four RBIs.
- Maikel Garcia is batting .288 with 38 doubles, five triples, 16 home runs and 60 walks.
- Garcia is 123rd in home runs and 76th in RBI among all major league hitters this year.
- Vinnie Pasquantino leads the Royals in home runs (31) and runs batted in (108).
- Salvador Perez is batting .242 with 34 doubles, 30 home runs and 26 walks.
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