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Bobby Witt Jr. and the Kansas City Royals face Steven Kwan and the Cleveland Guardians at Progressive Field on Wednesday. First pitch is at 6:40 p.m. ET. The Guardians are -109 moneyline underdogs for this matchup against the favored Royals (-111). Kansas City is favored on the run line (-1.5). The matchup’s total has been listed at 8 runs.
Here is everything you need to know from a betting perspective on the Royals-Guardians game, regarding the run line, moneyline and total, plus expert picks.
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Royals vs. Guardians Game Information & Odds
- When: Wednesday, September 10, 2025 at 6:40 p.m. ET
- Where: Progressive Field in Cleveland, Ohio
- How to watch on TV: CLEG and FDSKC
- Score Prediction: Guardians 5, Royals 4
- Total Prediction: Over 8 runs
- Win Probabilities: Royals 52%, Guardians 48%
- This season, the Royals have been favored 63 times and won 36, or 57.1%, of those games.
- Kansas City has entered 63 games this season favored by -111 or more and is 36-27 in those contests.
- The sportsbooks’ moneyline implies a 52.6% chance of a victory for the Royals.
- The Guardians have been chosen as underdogs in 82 games this year and have walked away with the win 37 times (45.1%) in those games.
- This year, Cleveland has won 37 of 82 games when listed as at least -109 or worse on the moneyline.
- The moneyline set for this matchup implies the Guardians have a 52.2% chance of coming away with a victory in the contest.
- The Royals were favored on the moneyline in six of their last 10 games, and they finished 2-4 in those matchups.
- Over their last 10 outings, the Royals and their opponents combined to go over the run total two times (all 10 of the games had set totals).
- The Royals’ ATS record is 2-8-0 over their past 10 games.
- Witt is the Royals best hitter thus far this season, hitting at a team-leading .294 rate along with 21 homers and 77 RBI.
- Witt ranks 59th in home runs and 41st in RBI among all batters in baseball.
- Maikel Garcia is batting .292 with 35 doubles, five triples, 16 home runs and 54 walks.
- Garcia is 107th in homers and 70th in RBI among all major league hitters this year.
- Vinnie Pasquantino leads the Royals with 29 home runs and 99 runs batted in.
- Salvador Perez has 33 doubles, 25 home runs and 23 walks while batting .237.
- In nine games over the last 10 matchups when set as underdogs by bookmakers, the Guardians had a record of 5-4.
- In their last 10 games with a total, the Guardians and their opponents have failed to hit the over six times.
- The Guardians have a record of 6-4-0 ATS over their last 10 games.
- Jose Ramirez leads the Guardians in home runs (27), runs batted in (75) and has put up a team-best batting average of .283.
- Ramirez’s home run total puts him 25th in MLB, and he is 47th in RBI.
- Ramirez brings a hitting streak of five games into this matchup. In his last five games he is hitting .400 with two doubles, a triple, a home run, a walk and five RBIs.
- Kwan is batting .277 with 25 doubles, a triple, 10 home runs and 49 walks.
- Kwan is currently 185th in home runs and 160th in RBI in the big leagues.
- Kyle Manzardo has 15 doubles, two triples, 25 home runs and 45 walks while batting .239.
- Angel Martinez has 21 doubles, a triple, 10 home runs and 17 walks while batting .226.
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