Eric Dane dead: ‘Grey’s Anatomy’ star does of ALS

Actor Eric Dane, best known for wooing “Grey’s Anatomy” audiences as plastic surgeon Dr. Mark “McSteamy” Sloan, has died following a public battle with ALS.

A TV star whose career spanned from “Saved by the Bell” to “Euphoria” and beyond, Dane died Thursday afternoon, his publicist announced in a statement. He was 53.

“With heavy hearts, we share that Eric Dane passed on Thursday afternoon following a courageous battle with ALS. He spent his final days surrounded by dear friends, his devoted wife, and his two beautiful daughters, Billie and Georgia, who were the center of his world,” the statement reads. “Throughout his journey with ALS, Eric became a passionate advocate for awareness and research, determined to make a difference for others facing the same fight. He will be deeply missed, and lovingly remembered always. Eric adored his fans and is forever grateful for the outpouring of love and support he’s received. The family has asked for privacy as they navigate this impossible time.”

Dane publicized his ALS diagnosis in April 2025. A former competitive swimmer and water polo player, he said ALS — also known as amyotrophic lateral sclerosis or Lou Gehrig’s disease — initially caused the right side of his body to stop working. Prior to his death, the actor channeled his personal experiences with the condition to portray a firefighter living with ALS on TV and advocated for legislation related to the condition.

In Shonda Rhimes’ “Grey’s Anatomy,” Dane’s Sloan was a welcome addition to Seattle Grace Hospital’s staff of heartthrobs who couldn’t seem to keep their gloved hands off each other amid shifts of wild and dramatic cases. He first appeared in Season 2 of “Grey’s Anatomy” in 2006. Sloan, within minutes of his arrival, takes a punch to the face from Patrick Dempsey’s Dr. Derek Shepherd and introduces himself to Ellen Pompeo’s Meredith Grey as one of the fellow “dirty mistresses” who broke up Shepherd’s marriage to ex-wife Dr. Addison Montgomery (Kate Walsh).

Dane had initially agreed to appear in only one episode of the long-running ABC drama, but remained a fixture — and eye candy for fans — for more than 130 episodes until 2012. Nicknamed “McSteamy” for his looks, Sloan pursued relationships with Drs. Lexie Grey (Chyler Leigh), Callie Torres (Sara Ramirez) and Teddy Altman (Kim Raver) over the course of Dane’s tenure. His character was killed off early in Season 9 after a devastating Season 8 plane crash that also claimed the life of Leigh’s Lexie.

In 2021, Dane returned to “Grey’s Anatomy” for a cameo in Meredith’s COVID-19-induced dreams.

Prior to breaking out with “Grey’s,” Dane played minor roles in series including “Saved by the Bell, “Roseanne,” “Gideon’s Crossing” and “Charmed.” Dane followed up his “Grey’s Anatomy” tenure with appearances on the ABC spinoff “Private Practice,” a leading role in TNT’s “The Last Ship” and a stint as a secretive real estate developer and dad in HBO’s teen drama “Euphoria.”

He also appeared in several movies following “Grey’s Anatomy,” including “X-Men: The Last Stand,” “Marley & Me,” “Burlesque” and Garry Marshall’s “Valentine’s Day,” which reunited him with co-star Dempsey.

Dane did not plan to be an actor until he unexpectedly landed a role in his high school’s production of Arthur Miller’s “All My Sons,” but he “fell in love with it,” he told the Gulf Times in 2014.

“I was like this is the greatest feeling ever,” he added.

Eric William Dane was born Nov. 9, 1972, in San Francisco. His father, a Navy man-turned-architect, died of a gunshot wound when the actor was 7, leaving his mother to raise her two children with assistance from her parents.

Dane attended Sequoia High School and San Mateo High School but dropped out prior to graduation to pursue acting in Los Angeles.

He partied often in his 20s and first entered rehab at age 26. Amid his “Grey’s Anatomy” fame, Dane struggled with addition to painkillers and prescription medicine. He relapsed in 2007 during the Writer’s Guild of America strike, he recalled in 2024.

“If you take the whole eight years I was on ‘Grey’s Anatomy,’ I was f— up longer than I was sober and that was when things started going sideways for me,” he said at the time. Notably, he entered rehab again in 2011 to address issues with prescription drugs he had been prescribed for a sports injury.

Dane also spoke openly about his struggles with depression, which reached a head in 2017 amid production on his series “The Last Ship.” During a 2017 “Today” appearance, Dane explained that he was taking medication to manage the disorder, which he said hit him “like a truck.”

“I had to take some time off,” he said at the time. “I went away, I took care of it, and I’m feeling great.”

Dane married “Loving” actor and model Rebecca Gayheart in 2004 in Las Vegas the same day he proposed to her. Infamously, their relationship was subject to scrutiny when in 2009 leaked video showed the spouses in the nude and intoxicated lounging in a bathtub with actor Kari Ann Peniche. Marty Singer, attorney for the spouses at the time, dismissed the controversy.

However, the couple separated in 2017 and Gayheart filed to divorce Dane in 2018, but the split was never finalized. Then in March 2025, right before he went public with his ALS, she filed a request to dismiss the original petition.

In Dane’s role after revealing his diagnosis, he appeared in an episode of the NBC medical drama “Brilliant Minds” as a heroic firefighter struggling to tell his family he has ALS. The episode aired in late November; Gayheart revealed in a late December New York magazine essay that the actor was receiving 24/7 nursing care and she was covering most of the caregivers’ missed shifts.

“We haven’t lived in the same home for eight years; he’s dated other people, I’ve dated someone,” Gayheart wrote in the essay, which discussed Dane’s diagnosis and how it had affected the family. “It’s a very complicated relationship, one that’s confusing for people. Our love may not be romantic, but it’s a familial love. Eric knows that I am always going to want the best for him. That I’m going to do my best to do right by him. And I know he would do the same for me.

“So whatever I can do or however I can show up to make this journey better for him or easier for him, I want to do that,” she continued. “And I want to model that for my girls: That’s what you do. That’s the right thing to do.”

Dane is survived by daughters Billie, 15, and Georgia, 14, whom he shares with Gayheart.