Royals vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 8:12 p.m.

The Wednesday schedule in MLB includes a matchup between the Kansas City Royals and the Baltimore Orioles.

Here’s everything you need to know before checking out today’s MLB odds and spreads on FanDuel Sportsbook.

• Kansas City Royals (7-16) vs. Baltimore Orioles (11-12)
• Date: Wednesday, April 22, 2026
• Time: 2:10 p.m. ET
• Venue: Kauffman Stadium — Kansas City, Missouri
• Coverage: Royals.TV and MASN

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-124) | BAL: (+106)
• Spread: KC: -1.5 (+164) | BAL: +1.5 (-200)
• Total: 9 — Over: (-122) | Under: (+100)

Royals vs Orioles Probable Starting Pitchers

Probable Pitchers: Michael Wacha (Royals) – 2-0, 1.00 ERA vs Chris Bassitt (Orioles) – 0-2, 6.19 ERA

The probable pitchers are Michael Wacha (2-0) for the Royals and Chris Bassitt (0-2) for the Orioles. Wacha and his team are 2-2-0 ATS this season when he starts. Wacha’s team won his only start as a favorite this season. When Bassitt starts, the Orioles have gone 2-2-0 against the spread. The Orioles have a 2-1 record in Bassitt’s three starts this season when they were the moneyline underdog.

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (56.4%)

• Baltimore is the underdog, +106 on the moneyline, while Kansas City is a -124 favorite at home.

• The Orioles are at the Royals, and are +1.5 on the runline. The Orioles are +164 to cover the spread, and the Royals are -200.

• The over/under for Royals-Orioles on April 22 is 9. The over is -122, and the under is +100.

Bet on Kansas City Royals vs. Baltimore Orioles on FanDuel today!

• The Royals have been favorites in nine games this season and have come away with the win four times (44.4%) in those contests.
• Kansas City has a record of 3-3 in contests when bookmakers favor them by -124 or more on the moneyline.
• The Royals and their opponents have hit the over in seven of their 21 games with a total set by oddsmakers this season.
• In 21 games with a line this season, the Royals have a mark of 8-13-0 against the spread.
• The Orioles have compiled a 2-6 record in games they were the underdog on the moneyline (winning 25% of those games).
• Baltimore has a record of 1-3 in games it has played as a moneyline underdog with odds of +106 or longer (25%).
• The Orioles have played in 23 games with an over/under set, and have combined with their opponents to go over the total 13 times (13-10-0).
• The Orioles are 9-14-0 against the spread this season.

Royals Player Leaders

• Maikel Garcia leads Kansas City in slugging percentage (.402) thanks to eight extra-base hits. He has a .272 batting average and an on-base percentage of .333.
• Among the qualifying hitters in MLB, his batting average ranks 55th, his on-base percentage ranks 83rd, and he is 85th in slugging.
• Bobby Witt Jr. leads the Royals with an OPS of .726. He has a slash line of .287/.370/.356 this season.
• His batting average is 37th among qualified players, his on-base percentage 42nd, and his slugging percentage 122nd.
• Witt heads into this matchup looking to extend his three-game hit streak. In his last five games he is batting .400 with three doubles, two walks and two RBIs.
• Carter Jensen has 15 hits and is batting .238 this season.
• Jensen enters this game with two games in a row with at least one hit. During his last five outings he is batting .278 with a home run, three walks and three RBIs.
• Vinnie Pasquantino is batting .149 with a .240 OBP and 11 RBI for Kansas City this season.

Orioles Player Leaders

• Taylor Ward has a .394 on-base percentage and a .457 slugging percentage, both team-high marks for the Orioles. He’s batting .293.
• Including all the qualifying hitters in the big leagues, his batting average ranks 30th, his on-base percentage ranks 17th, and he is 59th in slugging.
• Ward brings a three-game hitting streak into this matchup. During his last five outings he is batting .263 with two doubles, a home run, five walks and three RBIs.
• Gunnar Henderson is batting .196 with three doubles, a triple, seven home runs and 11 walks. He’s slugging .464 with an on-base percentage of .282.
• Including all qualified hitters, his batting average puts him 156th, his on-base percentage ranks 146th, and he is 54th in slugging.
• Jeremiah Jackson has 21 hits, a team-best for the Orioles.
• Leody Taveras has three doubles, two home runs and nine walks while hitting .341.

• 4/20/2026: 7-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/4/2025: 11-6 KC (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/3/2025: 4-0 KC (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/2/2025: 3-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/6/2025: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/5/2025: 8-1 BAL (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/4/2025: 8-2 KC (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 10/2/2024: 2-1 KC (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 10/1/2024: 1-0 KC (Favorite: Orioles, Spread: -1.5, Total: 7, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/21/2024: 5-0 BAL (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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