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The ‘Grey’s Anatomy’ Cast Sum Up Season 22 Premiere as ‘Deadly,’ A ‘Clean-Up Job’ and More

Story Center by Story Center
September 27, 2025
Reading Time: 5 mins read
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Meredith-Grey-Greys-Anatomy-Season-22-Premiere-inline-178594_0453.

The Grey’s Anatomy cast has seemingly confirmed that fans are right to be worried about whether their favorite characters survive the season 22 premiere.

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“The premiere in one word? Deadly,” Jason George, who plays surgical resident Ben Warren, quipped in a Saturday, September 27, Instagram video shared by the show’s official account.

His costar Kevin McKidd (Owen Hunt) chimed in to call the episode “breathtaking,” while Camilla Luddington (Jo Wilson) went with “jaw-dropping.” Anthony Hill (Winston Ndugu) later used the word “convalesces” and Alexis Floyd (Simone Griffith) chose “clean-up job.”

Newcomer Trevor Jackson, who will play one of the new surgical residents, further teased that the premiere is “fresh,” just as Kim Raver (Teddy Altman) hinted at plenty of drama.

Which ‘Grey’s Anatomy’ Stars Are — And Aren’t — Returning for Season 22 After Hospital Explosion?

“Edge of your seat,” Raver, 56, quipped.

The season 21 finale ended on a major cliffhanger after guest star Piper Perabo unknowingly brought a full tank of oxygen into an operating room at Grey Sloan Memorial. (Perabo, 48, thought the tank was empty, using it as a threat to get the doctors to perform a risky surgery on her chronically ill child.)

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By the end of the episode, fans learned that the tank actually wasn’t empty before there was an explosion on the O.R. floor. It’s not known which characters were safe from the blast as the likes of Atticus Lincoln (Chris Carmack) and Miranda Bailey (Chandra Wilson) were in respective surgeries. (Ellen Pompeo’s Meredith Grey and Luddington’s Jo, meanwhile, are likely safe since they were both spotted outside the medical facility at the time of the explosion.)

Ellen Pompeo. Disney/Anne Marie Fox)

The cast’s Saturday teaser further fueled speculation that one of the fan-favorite characters wouldn’t survive the blast.

“So it’s going to be Link or Miranda,” one social media user wrote in the Instagram comment section, with another pointing out, “Link isn’t in any of these teasers.”

A third fan sarcastically added, “Not stressed at all.”

Grey’s Anatomy’s Camilla Luddington, Harry Shum Jr. Reveal Who They Think Died Ahead of Season 22

Luddington, 41, previously told Us Weekly that she hoped Link would be alright. (Jo and Link are married and expecting a pair of twins when Grey’s returns.)

“I have no idea. I have a text chain going on with so many cast members that are like, ‘What do you think?’” Luddington exclusively told Us in June ahead of production. “We’ve seen too much, and we know too much.There’s not a single season I’m not worried about.”

She added, “I just hope [Link is] alive. And if there’s injury — what that is and what that looks like — I have no idea. So I feel like that is on my mind. I just hope that my [onscreen] husband is OK. Because she’s gonna need that support and they need it from each other. So I think it’s gonna throw a wrench in things and it’s gonna be a lot. They have two kids and two kids on the way.”

Showrunner Meg Marinis, meanwhile, had made it clear that no one was definitively safe.

“But even in the last two seasons with what you saw this year, we had to reduce the cast a little bit [because of industry-wide budget cuts], and everybody has very passionate feelings about their favorite characters,” Marinis told The Hollywood Reporter in May. “But if we can get the writers upset then we know we’re doing it right. It’s not as satisfying a story if people aren’t upset when someone leaves. It’s supposed to make people upset and sad, so I’m sure there’ll be some arguments. But I’ve been persuaded before to change my mind on things.”

Grey’s Anatomy season 22 premieres on ABC Thursday, October 9, at 10 p.m. ET.

‘ The preceding article may include information circulated by third parties ’

‘ Some details of this article were extracted from the following source www.yahoo.com ’

Tags: Anthony HillCamilla Luddingtonfavorite charactersgrey's anatomyJo WilsonKim RaverMeredith GreyMiranda BaileyOwen HuntPiper Perabosurgical residentTeddy Altman
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