Eric Dane, star of hit television shows “Grey’s Anatomy” and “Euphoria,” has died at 53.
Dane’s family shared a statement confirming his death with NBC News late Thursday.
“With heavy hearts, we share that Eric Dane passed on Thursday afternoon following a courageous battle with ALS. He spent his final days surrounded by dear friends, his devoted wife, and his two beautiful daughters, Billie and Georgia, who were the center of his world. Throughout his journey with ALS, Eric became a passionate advocate for awareness and research, determined to make a difference for others facing the same fight. He will be deeply missed, and lovingly remembered always. Eric adored his fans and is forever grateful for the outpouring of love and support he’s received. The family has asked for privacy as they navigate this impossible time.”
Dane’s big break arrived in the mid-2000s, when he was cast as Dr. Mark Sloan, aka McSteamy, on the ABC medical drama “Grey’s Anatomy,” a role he would play from 2006 until 2012 and reprise in 2021. In 2019, he did a complete 180 and became Cal Jacobs, a troubled married man, in HBO’s provocative drama, “Euphoria,” a role he continued in up until his death.
In April 2025, Dane announced he had been diagnosed with ALS, a progressive disease that attacks nerve cells controlling muscles throughout the body.
ALS gradually destroys the nerve cells and connections needed to walk, talk, speak and breathe. Most patients die within three to five years of a diagnosis.
Dane became an advocate for ALS awareness, speaking a news conference in Washington on health insurance prior authorization. “Some of you may know me from TV shows, such as “Grey’s Anatomy,” which I play a doctor. But I am here today to speak briefly as a patient battling ALS,” he said in June 2025. In September of that year, the ALS Network named Dane the recipient of their advocate of the year award, recognizing his commitment to raising awareness and support for people living with ALS.
The Amyotrophic lateral sclerosis, commonly known as Lou Gehrig’s Disease, is a neurological disease that affects nerve cells in the brain and spinal cord.
A memoir by Dane is scheduled to be published in late 2026. “Book of Days: A Memoir in Moments” will be released by Maria Shriver’s The Open Field, a Penguin Random House imprint. According to Open Field, Dane will look back upon key moments in his life, from his first day at work on “Grey’s Anatomy” to the births of his two daughters and learning that he has ALS.
“I want to capture the moments that shaped me — the beautiful days, the hard ones, the ones I never took for granted — so that if nothing else, people who read it will remember what it means to live with heart,” Dane said in a statement around the book’s announcement. “If sharing this helps someone find meaning in their own days, then my story is worth telling.”
Dane is survived by his wife, actor Rebecca Gayheart, and their two teen daughters, Billie Beatrice and Georgia Geraldine. Gayheart and Dane wed in 2004 and separated in September 2017. Gayheart filed for divorce in 2018, but later filed to dismiss the petition. In a December essay for New York magazine’s The Cut reflecting on Dane’s diagnosis, Gayheart called their dynamic “a very complicated relationship, one that’s confusing for people.” She said they never got a divorce, but dated other people and lived separately.
“Our love may not be romantic, but it’s a familial love,” she said. “Eric knows that I am always going to want the best for him. That I’m going to do my best to do right by him. And I know he would do the same for me. So whatever I can do or however I can show up to make this journey better for him or easier for him, I want to do that.”
Eric Dane is opening up about the emotional road ahead after a devastating health update. The “Grey’s Anatomy” alum was diagnosed with ALS earlier this year and reflected on the news in his first sit-down interview since going public with his illness.
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